About the Authors

Matthew C. Clifton

swu@broadinstitute.org (MS-W); mclifton@be4.com (MCC)

Affiliation Beryllium, Bedford, Massachusetts, United States of America

David M. Dranow

Affiliation Beryllium, Bedford, Massachusetts, United States of America

Alison Leed

Affiliation The Broad Institute, Cambridge, Massachusetts, United States of America

Ben Fulroth

Affiliation The Broad Institute, Cambridge, Massachusetts, United States of America

James W. Fairman

Affiliation Beryllium, Bedford, Massachusetts, United States of America

Jan Abendroth

Affiliation Beryllium, Bedford, Massachusetts, United States of America

Kateri A. Atkins

Affiliation Beryllium, Bedford, Massachusetts, United States of America

Ellen Wallace

Affiliation Beryllium, Bedford, Massachusetts, United States of America

Dazhong Fan

Affiliation Acme Bioscience, Palo Alto, California, United States of America

Guoping Xu

Affiliation Acme Bioscience, Palo Alto, California, United States of America

Z. J. Ni

Affiliation Acme Bioscience, Palo Alto, California, United States of America

Doug Daniels

Affiliation The Broad Institute, Cambridge, Massachusetts, United States of America

John Van Drie

Affiliation Van Drie Research, North Andover, Massachusetts, United States of America

Guo Wei

Affiliation The Broad Institute, Cambridge, Massachusetts, United States of America

Alex B. Burgin

Affiliation The Broad Institute, Cambridge, Massachusetts, United States of America

Todd R. Golub

Affiliations The Broad Institute, Cambridge, Massachusetts, United States of America, Dana-Farber Cancer Institute and Howard Hughes Medical Institute, Boston, Massachusetts, United States of America

Brian K. Hubbard

Affiliation The Broad Institute, Cambridge, Massachusetts, United States of America

Michael H. Serrano-Wu

swu@broadinstitute.org (MS-W); mclifton@be4.com (MCC)

Affiliation The Broad Institute, Cambridge, Massachusetts, United States of America

Competing Interests

DF, ZN, and GX are employees of Acme Bioscience. JVD is the sole proprietor of Van Drie Research. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MCC D. Daniels JVD GW AB TG BH MSW. Performed the experiments: D. Dranow AL BF JF JA KA EW DF GX ZN. Analyzed the data: MCC D. Dranow AL BF JF JA KA EW DF GX ZN. Wrote the paper: MCC MSW.