About the Authors

Takeo Nakanishi

Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Yoshitaka Hasegawa

Contributed equally to this work with: Yoshitaka Hasegawa, Reo Mimura

Current address: Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co., Ltd, Saitama, Japan

Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Reo Mimura

Contributed equally to this work with: Yoshitaka Hasegawa, Reo Mimura

Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Tomohiko Wakayama

Affiliation Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Yuka Uetoko

Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Hisakazu Komori

Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Shin-ichi Akanuma

Affiliation Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

Ken-ichi Hosoya

Affiliation Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

Ikumi Tamai

tamai@p.kanazawa-u.ac.jp

Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

Competing Interests

The authors have the following Competing Interests: This study was supported by a grant from Ono Pharmaceutical Co., Ltd. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TN IT. Performed the experiments: TN YH RM YU TW SA. Analyzed the data: TN YH RM TW IT. Contributed reagents/materials/analysis tools: TN HK SA KH. Wrote the paper: TN IT.