About the Authors
- Takeo Nakanishi
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Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
- Yoshitaka Hasegawa
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Contributed equally to this work with: Yoshitaka Hasegawa, Reo Mimura
Current address: Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co., Ltd, Saitama, Japan
Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
- Reo Mimura
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Contributed equally to this work with: Yoshitaka Hasegawa, Reo Mimura
Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
- Tomohiko Wakayama
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Affiliation Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
- Yuka Uetoko
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Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
- Hisakazu Komori
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Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
- Shin-ichi Akanuma
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Affiliation Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
- Ken-ichi Hosoya
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Affiliation Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
- Ikumi Tamai
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* E-mail: tamai@p.kanazawa-u.ac.jp
Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
Competing Interests
The authors have the following Competing Interests: This study was supported by a grant from Ono Pharmaceutical Co., Ltd. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: TN IT. Performed the experiments: TN YH RM YU TW SA. Analyzed the data: TN YH RM TW IT. Contributed reagents/materials/analysis tools: TN HK SA KH. Wrote the paper: TN IT.