About the Authors

Cristian Vilos

Affiliations Center for Integrative Medicine and Innovative Science (CIMIS), Universidad Andres Bello, Facultad de Medicina, Santiago, Chile, Centro para el Desarrollo de la Nanociencia y Nanotecnología, (CEDENNA). Universidad de Santiago de Chile, Santiago, Chile

Luis A. Velasquez

Affiliations Center for Integrative Medicine and Innovative Science (CIMIS), Universidad Andres Bello, Facultad de Medicina, Santiago, Chile, Centro para el Desarrollo de la Nanociencia y Nanotecnología, (CEDENNA). Universidad de Santiago de Chile, Santiago, Chile

Paula I. Rodas

Affiliation Center for Integrative Medicine and Innovative Science (CIMIS), Universidad Andres Bello, Facultad de Medicina, Santiago, Chile

Katherine Zepeda

Affiliation Center for Integrative Medicine and Innovative Science (CIMIS), Universidad Andres Bello, Facultad de Medicina, Santiago, Chile

Soung-Jae Bong

Affiliation Center for Integrative Medicine and Innovative Science (CIMIS), Universidad Andres Bello, Facultad de Medicina, Santiago, Chile

Natalia Herrera

Affiliation Center for Integrative Medicine and Innovative Science (CIMIS), Universidad Andres Bello, Facultad de Medicina, Santiago, Chile

Mario Cantin

Affiliations CIMA, Department of Integral Dentistry, Faculty of Dentistry, Universidad de La Frontera, Temuco, Chile, Center of Research in Biomedical Sciences, Universidad Autónoma de Chile, Temuco, Chile

Felipe Simon

Affiliation Laboratorio de Fisiopatología Integrativa, Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas and Facultad de Medicina, Universidad Andrés Bello, Santiago, Chile

Luis Constandil

luis.constandil@usach.cl

Affiliations Centro para el Desarrollo de la Nanociencia y Nanotecnología, (CEDENNA). Universidad de Santiago de Chile, Santiago, Chile, Laboratorio de Neurobiología, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile

Competing Interests

The authors CV and LV declare the patent application number PCT/CL2012/000066, "Injectable veterinary composition for sustained release of ceftiofur and florfenicol in animal species, which comprises poly(lacticcoglycolic acid) (plga) microparticles, and the method for the preparation thereof" relating to material pertinent to this article, also published as WO 2013071456 A2, and WO2013071456A3. The patent application does not alter the adherence to all PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors http://www.PLOSone.org/static/editorial.action#competing.

Author Contributions

Conceived and designed the experiments: CV LC LV PR. Performed the experiments: CV PR LC NH KZ. Analyzed the data: CV LC FS LV MC PR KZ. Contributed reagents/materials/analysis tools: LC LV CV. Wrote the paper: CV LC SJ LV.