About the Authors

Ljubica Perisic

Affiliations Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden, Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden

Patricia Q. Rodriguez

Current address: KI/AZ Integrated CardioMetabolic Center, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden

Affiliation Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

Kjell Hultenby

Affiliation Clinical Research Center, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden

Ying Sun

Current address: Translational Science Center, Personalized Healthcare and Biomarkers, R&D, AstraZeneca, Stockholm, Sweden

Affiliation Vascular Biology Division, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

Mark Lal

Current address: AstraZeneca, Bioscience, Mölndal, Sweden

Affiliation Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

Christer Betsholtz

Affiliation Vascular Biology Division, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

Mathias Uhlén

Affiliation Department of Biotechnology, Royal Institute of Technology, Stockholm, Sweden

Annika Wernerson

Affiliation Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden

Ulf Hedin

Affiliation Division of Vascular Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden

Timo Pikkarainen

Current address: Laboratory of Developmental Biology, Department of Medical Biochemistry and Molecular Biology, Biocenter Oulu, University of Oulu, Oulu, Finland

Affiliation Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

Karl Tryggvason

Affiliation Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

Jaakko Patrakka

jaakko.patrakka@ki.se

Current address: KI/AZ Integrated CardioMetabolic Center, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden

Affiliation Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JP KT LP TP. Performed the experiments: LP PQR KH YS. Analyzed the data: LP PQR TP KT JP. Contributed reagents/materials/analysis tools: MU AÖW CB. Wrote the paper: LP PQR ML UH CB TP KT JP.