About the Authors

Yoshie Takizawa

Affiliation Department of Food Science & Nutrition, Nara Women’s University, Nara, Japan

Rieko Nakata

Affiliation Department of Food Science & Nutrition, Nara Women’s University, Nara, Japan

Kiyoshi Fukuhara

Affiliation Showa University School of Pharmacy, Tokyo, Japan

Hiroshi Yamashita

Affiliation Medicinal Chemistry Research Laboratories, Mitsubishi Tanabe Pharma Corporation, Kanagawa, Japan

Hideo Kubodera

Affiliation Medicinal Chemistry Research Laboratories, Mitsubishi Tanabe Pharma Corporation, Kanagawa, Japan

Hiroyasu Inoue

inoue@cc.nara-wu.ac.jp

Affiliation Department of Food Science & Nutrition, Nara Women’s University, Nara, Japan

Competing Interests

All authors have declared that no competing interests exist in this revised manuscript. Two of the authors are employed by a commercial company, Medicinal Chemistry Research Laboratories, Mitsubishi Tanabe Pharma Corporation, Kanagawa, Japan. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YT RN HI. Performed the experiments: YT RN HY HK HI. Analyzed the data: YT RN HY HK HI. Contributed reagents/materials/analysis tools: YT RN KF HY HK HI. Wrote the paper: YT RN HY HK HI.