About the Authors

Rhonda C. Kines

Current address: Aura Biosciences, Cambridge, Massachusetts, United States of America

Affiliation Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Vladimir Zarnitsyn

Affiliation School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

Teresa R. Johnson

Affiliation Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Yuk-Ying S. Pang

Affiliation Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Kizzmekia S. Corbett

Affiliation Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

John D. Nicewonger

Affiliation Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Anu Gangopadhyay

Affiliation Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Man Chen

Affiliation Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Jie Liu

Affiliation Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Mark R. Prausnitz

Affiliation School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

John T. Schiller

Affiliation Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Barney S. Graham

bgraham@nih.gov

Affiliation Viral Pathogenesis Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

R.C.K., J.T.S. and B.S.G. have submitted a patent application related to the use of HPV PsVencapsidated plasmids; patent name: “Use of HPV Virus-Like Particles to Deliver Gene-Based Vaccines”, and number: U.S. Provisional Patent Application No. 60/022,324 filed January 19, 2008. PCT Application No. PCT/US2009/031600 filed 21 Jan 2009. US Application No. 12/863,572 filed 19 Jul 2010. M.R.P. is an inventor of patents that have been licensed to companies developing microneedle-based products unrelated to this study, is a paid advisor to companies developing microneedle-based products and is a founder/shareholder of companies developing microneedle-based products. This potential conflict of interest has been disclosed and is managed by Georgia Tech and Emory University. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RCK VZ TRJ MRP JTS BSG. Performed the experiments: RCK VZ TRJ YSP KC JDN AG MC JL. Analyzed the data: RCK VZ TRJ BSG. Contributed reagents/materials/analysis tools: RCK VZ TRJ MRP JTS BSG. Wrote the paper: RCK VZ TRJ MRP JTS BSG.