About the Authors

Kim Pauwels

Kim.Pauwels@pharm.kuleuven.be

Affiliation KU Leuven Department of Pharmaceutical and Pharmacological Sciences, 3000, Leuven, Belgium

Steven Simoens

Affiliation KU Leuven Department of Pharmaceutical and Pharmacological Sciences, 3000, Leuven, Belgium

Minne Casteels

Affiliation KU Leuven Department of Pharmaceutical and Pharmacological Sciences, 3000, Leuven, Belgium

Isabelle Huys

Affiliation KU Leuven Department of Pharmaceutical and Pharmacological Sciences, 3000, Leuven, Belgium

Competing Interests

The work was financially supported by TEVA. The research was carried out independently by KU Leuven and the final manuscript was approved by TEVA. None of the authors is employed by TEVA. MC is member of the Scientific Advice Working Party at EMA. The authors have declared that no other competing interests exist. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KP SS MC IH. Performed the experiments: KP SS MC IH. Analyzed the data: KP SS MC IH. Contributed reagents/materials/analysis tools: KP SS MC IH. Wrote the paper: KP SS MC IH.