About the Authors

Olya Grove

Affiliation Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America

Anders E. Berglund

Affiliation Department of Biomedical Informatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America

Matthew B. Schabath

Affiliation Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America

Hugo J. W. L. Aerts

Affiliations Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States of America, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States of America

Andre Dekker

Affiliation Department of Radiation Oncology, MAASTRO clinic, Research Institute GROW, Maastricht University, 6229ET Maastricht, The Netherlands

Hua Wang

Affiliations Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America, Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

Emmanuel Rios Velazquez

Affiliation Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States of America

Philippe Lambin

Affiliation Department of Radiation Oncology, MAASTRO clinic, Research Institute GROW, Maastricht University, 6229ET Maastricht, The Netherlands

Yuhua Gu

Affiliation Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America

Yoganand Balagurunathan

Affiliation Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America

Edward Eikman

Affiliation Department of Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America

Robert A. Gatenby

Affiliations Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America, Department of Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America

Steven Eschrich

Affiliation Department of Biomedical Informatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America

Robert J. Gillies

Robert.Gillies@Moffitt.org

Affiliations Department of Cancer Imaging and Metabolism, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America, Department of Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America

Competing Interests

Dr. Schabath is a PLOS ONE Editorial Board member and the authors confirm that this does not alter their adherence to PLOS ONE Editorial policies and criteria.

Author Contributions

Conceived and designed the experiments: OG AEB SE RJG AD RAG. Performed the experiments: OG AEB SE RJG YG ERV HW EE. Analyzed the data: OG MBS HJA AEB YB SE. Contributed reagents/materials/analysis tools: OG AEB MBS HJA SE. Wrote the paper: OG AEB MBS HJA AD HW ERV PL YG YB EE RAG SE RJG.