About the Authors

Yasuhisa Ano

Yasuhisa_Ano@kirin.co.jp

Affiliation Central Laboratories for Key Technologies, Kirin Company Ltd, 1–13–5 Fukuura Kanazawa-ku, Yokohama-shi, Kanagawa, 236–0004, Japan

Toshiko Kutsukake

Affiliation Central Laboratories for Key Technologies, Kirin Company Ltd, 1–13–5 Fukuura Kanazawa-ku, Yokohama-shi, Kanagawa, 236–0004, Japan

Ayaka Hoshi

Affiliation Central Laboratories for Key Technologies, Kirin Company Ltd, 1–13–5 Fukuura Kanazawa-ku, Yokohama-shi, Kanagawa, 236–0004, Japan

Aruto Yoshida

Affiliation Central Laboratories for Key Technologies, Kirin Company Ltd, 1–13–5 Fukuura Kanazawa-ku, Yokohama-shi, Kanagawa, 236–0004, Japan

Hiroyuki Nakayama

Affiliation Graduate School of Agricultural and Life Sciences, the University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo, 113–8657, Japan

Competing Interests

The authors have the following interests. Yasuhisa Ano, Toshiko Kutsukake, Ayaka Hoshi and Aruto Yoshida are employed by Kirin Company Ltd. There are no products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: YA AY. Performed the experiments: YA TK AH. Analyzed the data: YA TK AH. Wrote the paper: HN.