Induction of CD44 Variant 9-Expressing Cancer Stem Cells Might Attenuate the Efficacy of Chemoradioselection and Worsens the Prognosis of Patients with Advanced Head and Neck Cancer

Takeichiro Aso; Mioko Matsuo; Hideyuki Kiyohara; Kenichi Taguchi; Fumihide Rikimaru; Mototsugu Shimokawa; Yuichi Segawa; Yuichiro Higaki; Hirohito Umeno; Tadashi Nakashima; Muneyuki Masuda

doi:10.1371/journal.pone.0116596

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Peer-reviewed

Research Article

Induction of CD44 Variant 9-Expressing Cancer Stem Cells Might Attenuate the Efficacy of Chemoradioselection and Worsens the Prognosis of Patients with Advanced Head and Neck Cancer

Takeichiro Aso,

Affiliation Department of Head and Neck Surgery, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan
⨯
Mioko Matsuo,

Affiliation Department of Head and Neck Surgery, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan
⨯
Hideyuki Kiyohara,

Affiliation Department of Head and Neck Surgery, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan
⨯
Kenichi Taguchi,

Affiliation Department of Pathology, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan
⨯
Fumihide Rikimaru,

Affiliation Department of Head and Neck Surgery, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan
⨯
Mototsugu Shimokawa,

Affiliation Department of Cancer Information Research, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan
⨯
Yuichi Segawa,

Affiliation Department of Otorhinolaryngology and Head and Neck Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582, Japan
⨯
Yuichiro Higaki,

Affiliation Department of Head and Neck Surgery, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan
⨯
Hirohito Umeno,

Affiliation Department of Otorhinolaryngology and Head and Neck Surgery, School of Medicine, Kurume University, 67, Asahimachi, Fukuoka, 830-0011, Japan
⨯
Tadashi Nakashima,

Affiliation Department of Otorhinolaryngology and Head and Neck Surgery, School of Medicine, Kurume University, 67, Asahimachi, Fukuoka, 830-0011, Japan
⨯
Muneyuki Masuda

* E-mail: mmuneyuki@jcom.home.ne.jp

Affiliation Department of Head and Neck Surgery, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan
⨯

Induction of CD44 Variant 9-Expressing Cancer Stem Cells Might Attenuate the Efficacy of Chemoradioselection and Worsens the Prognosis of Patients with Advanced Head and Neck Cancer

Takeichiro Aso,
Mioko Matsuo,
Hideyuki Kiyohara,
Kenichi Taguchi,
Fumihide Rikimaru,
Mototsugu Shimokawa,
Yuichi Segawa,
Yuichiro Higaki,
Hirohito Umeno,
Tadashi Nakashima

Published: March 9, 2015
https://doi.org/10.1371/journal.pone.0116596

About the Authors

Takeichiro Aso

Affiliation Department of Head and Neck Surgery, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan

Mioko Matsuo

Affiliation Department of Head and Neck Surgery, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan

Hideyuki Kiyohara

Affiliation Department of Head and Neck Surgery, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan

Kenichi Taguchi

Affiliation Department of Pathology, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan

Fumihide Rikimaru

Affiliation Department of Head and Neck Surgery, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan

Mototsugu Shimokawa

Affiliation Department of Cancer Information Research, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan

Yuichi Segawa

Affiliation Department of Otorhinolaryngology and Head and Neck Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka 812-8582, Japan

Yuichiro Higaki

Affiliation Department of Head and Neck Surgery, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan

Hirohito Umeno

Affiliation Department of Otorhinolaryngology and Head and Neck Surgery, School of Medicine, Kurume University, 67, Asahimachi, Fukuoka, 830-0011, Japan

Tadashi Nakashima

Affiliation Department of Otorhinolaryngology and Head and Neck Surgery, School of Medicine, Kurume University, 67, Asahimachi, Fukuoka, 830-0011, Japan

Muneyuki Masuda

* E-mail: mmuneyuki@jcom.home.ne.jp

Affiliation Department of Head and Neck Surgery, National Kyushu Cancer Center, 3-1-1, Notame, Minamiku, Fukuoka 811-1395, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TA YH HU TN M. Masuda. Performed the experiments: TA KT YS. Analyzed the data: TA MM HK FR MS. Contributed reagents/materials/analysis tools: KT. Wrote the paper: TA M. Masuda.

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Head and neck cancers
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Biopsy
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Cancer stem cells
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Surgical and invasive medical procedures
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Cancer treatment
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Larynx
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Cancers and neoplasms
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Nasopharyngeal carcinoma
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