About the Authors

Bryan R. Gorman

Affiliations Department Of Pediatric Newborn Medicine and Department of Medicine, Division of Genetics, Brigham and Women's Hospital; Harvard Medical School; Harvard Stem Cell Institute, Boston, Massachusetts, United States of America, Harvard-MIT Division Of Health Sciences and Technology, Massachusetts Institute Of Technology, Cambridge, Massachusetts, United States of America, Charles Stark Draper Laboratory, Cambridge, Massachusetts, United States of America

Junjie Lu

Affiliation Department Of Pediatric Newborn Medicine and Department of Medicine, Division of Genetics, Brigham and Women's Hospital; Harvard Medical School; Harvard Stem Cell Institute, Boston, Massachusetts, United States of America

Anna Baccei

Affiliation Department Of Pediatric Newborn Medicine and Department of Medicine, Division of Genetics, Brigham and Women's Hospital; Harvard Medical School; Harvard Stem Cell Institute, Boston, Massachusetts, United States of America

Nathan C. Lowry

Affiliation Charles Stark Draper Laboratory, Cambridge, Massachusetts, United States of America

Jeremy E. Purvis

Affiliation Department Of Genetics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

Rami S. Mangoubi

Affiliation Charles Stark Draper Laboratory, Cambridge, Massachusetts, United States of America

Paul H. Lerou

plerou@partners.org

Affiliation Department Of Pediatric Newborn Medicine and Department of Medicine, Division of Genetics, Brigham and Women's Hospital; Harvard Medical School; Harvard Stem Cell Institute, Boston, Massachusetts, United States of America

Competing Interests

R.S.M. and N.L. are employed by C.S. Draper Laboratory, which holds patents in image analysis methods applied to stem cells, none of which are directly related to this work. B.G. is an unpaid student affiliate of C.S. Draper Laboratory. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BRG JL JEP RSM PHL. Performed the experiments: BRG JL AB. Analyzed the data: BRG NCL RSM JEP JL PHL. Contributed reagents/materials/analysis tools: BRG AB JL RSM NCL JEP PHL. Wrote the paper: BRG JL PHL RSM.