Analysis of Cathepsin and Furin Proteolytic Enzymes Involved in Viral Fusion Protein Activation in Cells of the Bat Reservoir Host

Farah El Najjar; Levi Lampe; Michelle L. Baker; Lin-Fa Wang; Rebecca Ellis Dutch

doi:10.1371/journal.pone.0115736

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Open Access

Peer-reviewed

Research Article

Analysis of Cathepsin and Furin Proteolytic Enzymes Involved in Viral Fusion Protein Activation in Cells of the Bat Reservoir Host

Farah El Najjar,

Affiliation Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Levi Lampe,

Affiliation Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Michelle L. Baker,

Affiliation CSIRO Australian Animal Health Laboratory, East Geelong, Victoria, Australia
⨯
Lin-Fa Wang,

Affiliations CSIRO Australian Animal Health Laboratory, East Geelong, Victoria, Australia, Program in Emerging Infectious Diseases, Duke–National University of Singapore Graduate Medical School, Singapore, Singapore
⨯
Rebecca Ellis Dutch

* E-mail: rdutc2@uky.edu

Affiliation Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America
⨯

Analysis of Cathepsin and Furin Proteolytic Enzymes Involved in Viral Fusion Protein Activation in Cells of the Bat Reservoir Host

Farah El Najjar,
Levi Lampe,
Michelle L. Baker,
Lin-Fa Wang,
Rebecca Ellis Dutch

Published: February 23, 2015
https://doi.org/10.1371/journal.pone.0115736

About the Authors

Farah El Najjar

Affiliation Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America

Levi Lampe

Affiliation Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America

Michelle L. Baker

Affiliation CSIRO Australian Animal Health Laboratory, East Geelong, Victoria, Australia

Lin-Fa Wang

Affiliations CSIRO Australian Animal Health Laboratory, East Geelong, Victoria, Australia, Program in Emerging Infectious Diseases, Duke–National University of Singapore Graduate Medical School, Singapore, Singapore

Rebecca Ellis Dutch

* E-mail: rdutc2@uky.edu

Affiliation Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FEN LL MB LW RD. Performed the experiments: FEN LL MB. Analyzed the data: FEN LL MB LW RD. Contributed reagents/materials/analysis tools: LW RD. Wrote the paper: FEN MB LW RD.

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Fruit bats
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Hendra virus
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Proteases
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Vero cells
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Bats
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Membrane proteins
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Cell fusion
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Transfection
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