About the Authors

Anna Lutz

Contributed equally to this work with: Anna Lutz, Julia Sanwald

Affiliation Department of Pharmaceutical Biology and Biotechnology, Albert Ludwigs University Freiburg, Freiburg, Germany

Julia Sanwald

Contributed equally to this work with: Anna Lutz, Julia Sanwald

Affiliation Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany

Maria Thomas

Affiliation Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany

Ronny Feuer

Affiliation Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany

Oliver Sawodny

Affiliation Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany

Michael Ederer

Affiliation Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany

Christoph Borner

Affiliations Institute of Molecular Medicine and Cell Research, Albert Ludwigs University Freiburg, Freiburg, Germany, Spemann Graduate School of Biology and Medicine (SGBM), Albert Ludwigs University Freiburg, Freiburg, Germany, Bioss – Centre for Biological Signaling Studies, Albert Ludwigs University Freiburg, Freiburg, Germany

Matjaz Humar

Affiliation Department of Pharmaceutical Biology and Biotechnology, Albert Ludwigs University Freiburg, Freiburg, Germany

Irmgard Merfort

irmgard.merfort@pharmazie.uni-freiburg.de

Affiliations Department of Pharmaceutical Biology and Biotechnology, Albert Ludwigs University Freiburg, Freiburg, Germany, Spemann Graduate School of Biology and Medicine (SGBM), Albert Ludwigs University Freiburg, Freiburg, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AL JS IM. Performed the experiments: AL MT MH. Analyzed the data: AL JS MT MH IM. Contributed reagents/materials/analysis tools: MT CB IM. Wrote the paper: AL JS CB MH IM. Mathematical modeling: JS ME RF OS.