Human Cerberus Prevents Nodal-Receptor Binding, Inhibits Nodal Signaling, and Suppresses Nodal-Mediated Phenotypes

Senem Aykul; Wendi Ni; Washington Mutatu; Erik Martinez-Hackert

doi:10.1371/journal.pone.0114954

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Open Access

Peer-reviewed

Research Article

Human Cerberus Prevents Nodal-Receptor Binding, Inhibits Nodal Signaling, and Suppresses Nodal-Mediated Phenotypes

Senem Aykul,

Affiliation Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, United States of America
⨯
Wendi Ni,

Affiliation Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, United States of America
⨯
Washington Mutatu,

Affiliation Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, United States of America
⨯
Erik Martinez-Hackert

* E-mail: emh@msu.edu

Affiliation Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, United States of America
⨯

Human Cerberus Prevents Nodal-Receptor Binding, Inhibits Nodal Signaling, and Suppresses Nodal-Mediated Phenotypes

Senem Aykul,
Wendi Ni,
Washington Mutatu,
Erik Martinez-Hackert

Published: January 20, 2015
https://doi.org/10.1371/journal.pone.0114954

About the Authors

Senem Aykul

Affiliation Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, United States of America

Wendi Ni

Affiliation Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, United States of America

Washington Mutatu

Affiliation Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, United States of America

Erik Martinez-Hackert

* E-mail: emh@msu.edu

Affiliation Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SA EMH. Performed the experiments: SA WN. Analyzed the data: SA EMH. Contributed reagents/materials/analysis tools: SA WM EMH. Wrote the paper: EMH.

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Breast cancer
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Chemical dissociation
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Phosphorylation
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Coreceptors
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Curve fitting
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Signal inhibition
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Cancer treatment
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Luciferase
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