About the Authors

Inna Dubchak

Contributed equally to this work with: Inna Dubchak, Sandhya Balasubramanian

ildubchak@lbl.gov (ID); maltsev@uchicago.edu (NM)

Affiliations Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, Department of Energy Joint Genome Institute, Walnut Creek, California, United States of America

Sandhya Balasubramanian

Contributed equally to this work with: Inna Dubchak, Sandhya Balasubramanian

Affiliation Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

Sheng Wang

Affiliation Toyota Technological Institute at Chicago, Chicago, Illinois, United States of America

Cem Meyden

Affiliations Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York, United States of America, The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York, United States of America, Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York, United States of America

Dinanath Sulakhe

Affiliations Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Computation Institute, University of Chicago/Argonne National Laboratory, Chicago, Illinois, United States of America

Alexander Poliakov

Affiliation Department of Energy Joint Genome Institute, Walnut Creek, California, United States of America

Daniela Börnigen

Affiliations Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Toyota Technological Institute at Chicago, Chicago, Illinois, United States of America

Bingqing Xie

Affiliations Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Department of Computer Science, Illinois Institute of Technology, Chicago, Illinois, United States of America

Andrew Taylor

Affiliation Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

Jianzhu Ma

Affiliation Toyota Technological Institute at Chicago, Chicago, Illinois, United States of America

Alex R. Paciorkowski

Affiliation Departments of Neurology, Pediatrics, and Biomedical Genetics and Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, New York, United States of America

Ghayda M. Mirzaa

Affiliation Seattle Children's Research Institute and Department of Pediatrics, University of Washington, Seattle, Washington, United States of America

Paul Dave

Affiliation Computation Institute, University of Chicago/Argonne National Laboratory, Chicago, Illinois, United States of America

Gady Agam

Affiliation Department of Computer Science, Illinois Institute of Technology, Chicago, Illinois, United States of America

Jinbo Xu

Affiliation Toyota Technological Institute at Chicago, Chicago, Illinois, United States of America

Lihadh Al-Gazali

Affiliation Department of Pediatrics, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, UAE

Christopher E. Mason

Affiliations Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York, United States of America, The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York, United States of America, Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York, United States of America

M. Elizabeth Ross

Affiliation Laboratory of Neurogenetics and Development, Weill Cornell Medical College, New York, New York, United States of America

Natalia Maltsev

ildubchak@lbl.gov (ID); maltsev@uchicago.edu (NM)

Affiliations Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Computation Institute, University of Chicago/Argonne National Laboratory, Chicago, Illinois, United States of America

T. Conrad Gilliam

Affiliations Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Computation Institute, University of Chicago/Argonne National Laboratory, Chicago, Illinois, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ID MER CEM NM TCG. Performed the experiments: CM LA. Analyzed the data: SB SW AP JM. Contributed reagents/materials/analysis tools: DS DB BX AT ARP GMM PD GA JX. Wrote the paper: ID NM TCG SB SW MER CEM CM.