About the Authors

Minfeng Chen

Contributed equally to this work with: Minfeng Chen, Pengfei Song

Affiliations School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, 510006, China, BGI-Shenzhen, Shenzhen, 518083, China

Pengfei Song

Contributed equally to this work with: Minfeng Chen, Pengfei Song

Affiliation The fourth people's hospital of Shenzhen (Futian hospital), Shenzhen, 518033, China

Dan Zou

Affiliation School of Computer, National University of Defense Technology, Changsha, 410073, China

Xuesong Hu

Affiliation BGI-Shenzhen, Shenzhen, 518083, China

Shancen Zhao

lingfeiscut@gmail.com (FL); gaoshengjie@genomics.cn (SG); zhaoshancen@genomics.cn (SZ)

Affiliations BGI-Shenzhen, Shenzhen, 518083, China, Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark

Shengjie Gao

lingfeiscut@gmail.com (FL); gaoshengjie@genomics.cn (SG); zhaoshancen@genomics.cn (SZ)

Affiliations BGI-Shenzhen, Shenzhen, 518083, China, State Key Laboratory of Agrobiotechnology and School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China

Fei Ling

lingfeiscut@gmail.com (FL); gaoshengjie@genomics.cn (SG); zhaoshancen@genomics.cn (SZ)

Affiliation School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, 510006, China

Competing Interests

MC, XH, SZ & SG are employees of BGI-ShenZhen, whose company partly funded this study. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: FL SG SZ. Analyzed the data: MC PS DZ XH. Wrote the paper: SZ MC SG XH.