About the Authors

Said Rahim

Affiliation Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States of America

Tsion Minas

Affiliation Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States of America

Sung-Hyeok Hong

Affiliation Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States of America

Sarah Justvig

Affiliation Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States of America

Haydar Çelik

Affiliation Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States of America

Yasemin Saygideger Kont

Affiliation Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States of America

Jenny Han

Affiliation Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States of America

Abraham T. Kallarakal

Affiliation Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States of America

Yali Kong

Affiliation Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States of America

Michelle A. Rudek

Affiliation The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, United States of America

Milton L. Brown

Affiliation Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States of America

Bhaskar Kallakury

Affiliation Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States of America

Jeffrey A. Toretsky

Affiliation Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States of America

Aykut Üren

au26@georgetown.edu

Affiliation Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, United States of America

Competing Interests

The authors have read the journal's policy and the authors of this manuscript have the following competing interests: USPTO awarded for YK-4-279 to Georgetown University, inventors include. Y.K., M.B., J.T. and A.Ü. A license agreement has been executed between Georgetown University and Tokalas Inc for these patents, in which J.T. is a founding share-holder. Georgetown University has filed patent applications on the YK-4279 as well as related compounds and derivatives of those molecules. Below is a summary of the issued and pending patent applications related to these compounds. I. “Targeting of EWS-FLI as Anti-Tumor Therapy” (GU Reference # 2006-041) 1. US Provisional application (60/877,856) filed December 29, 2006. 2. PCT/US07/089118 filed December 28, 2007. 3. US Provisional application (61/177,932) filed May 13, 2009. 4. US Non-provisional 12/494,191 filed June 29, 2009 ((CIP) claiming priority to both the PCT and US provisional applications; national phase entry of PCT); issued as US Patent 8,232,310. 5. US Non-provisional 12/720,616 filed March 9, 2010 (CONT). 6. Europe 07872364.0 filed December 28, 2007 (national phase entry of PCT). 7. Canada 2,711,003 filed December 28, 2007 (national phase entry of PCT). 8. Australia 2007341977 filed December 28, 2007 (national phase entry of PCT). 9. United States Provisional 61/405,170 filed October 20, 2010 (contains additional data). 10. Europe 13186704.6 divisional of Europe 07872364.0 priority to December 28, 2007. II. “Methods and Compositions for Treating Ewings Sarcoma Family of Tumors” (GU Reference #2012-019) 1. US Provisional Patent Application 61/623,349 filed April 12, 2012. 2. Patent Cooperation Treaty Application PCT/US2013/036234 filed April 11, 2013. III. “Methods and Compositions for Treating Cancer” (GU Reference #2014-012) 1. US Provisional Patent Application 61/895,308 filed October 24, 2013. All data in the manuscript are freely available. The authors acknowledge and follow all PLOS ONE policies on sharing data and materials. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SR TM SHH SJ HC YSK JH ATK YK MAR MLB BK JAT AU. Performed the experiments: SR TM SHH SJ JH ATK MAR. Analyzed the data: SR SHH SJ ATK MAR BK AU. Contributed reagents/materials/analysis tools: SR HC YSK ATK YK MAR MLB BK JAT AU. Wrote the paper: SR AU.