About the Authors

Sohsuke Yamada

Contributed equally to this work with: Sohsuke Yamada, Tomoyuki Koyama

sousuke@med.uoeh-u.ac.jp

Affiliation Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

Tomoyuki Koyama

Contributed equally to this work with: Sohsuke Yamada, Tomoyuki Koyama

Affiliation Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo 108-8477, Japan

Hirotsugu Noguchi

Affiliation Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

Yuki Ueda

Affiliation Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo 108-8477, Japan

Ryo Kitsuyama

Affiliation Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka 020-8551, Japan

Hiroya Shimizu

Affiliation Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka 020-8551, Japan

Akihide Tanimoto

Affiliation Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan

Ke-Yong Wang

Affiliations Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan, Shared-Use Research Center, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

Aya Nawata

Affiliation Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

Toshiyuki Nakayama

Affiliation Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

Yasuyuki Sasaguri

Affiliations Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan, Laboratory of Pathology, Fukuoka Wajiro Hospital, Fukuoka 811-0213, Japan

Takumi Satoh

Affiliations Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka 020-8551, Japan, Department of Anti-Aging Food Research, School of Bioscience and Biotechnology, Tokyo University of Technology, Hachioji 192-0982, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SY TK TS. Performed the experiments: SY TK YU RK HS TS. Analyzed the data: SY TK HN YS TS. Contributed reagents/materials/analysis tools: AT KYW AN TN. Wrote the paper: SY TK TS. Contributed excellent technical assistance and helpful comments: AT TN YS.