Mitochondrial Complex 1 Inhibition Increases 4-Repeat Isoform Tau by SRSF2 Upregulation

Julius Bruch; Hong Xu; Anderson De Andrade; Günter Höglinger

doi:10.1371/journal.pone.0113070

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Open Access

Peer-reviewed

Research Article

Mitochondrial Complex 1 Inhibition Increases 4-Repeat Isoform Tau by SRSF2 Upregulation

Julius Bruch ,

Contributed equally to this work with: Julius Bruch, Hong Xu

Affiliations Department of Translational Neurodegeneration, German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany, Department of Neurology, Technische Universität München, Munich, Germany
⨯
Hong Xu ,

Contributed equally to this work with: Julius Bruch, Hong Xu

Affiliations Department of Translational Neurodegeneration, German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany, Department of Neurology, Technische Universität München, Munich, Germany
⨯
Anderson De Andrade,

Affiliation Department of Translational Neurodegeneration, German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany
⨯
Günter Höglinger

* E-mail: hoeglinger@lrz.tum.de

Affiliations Department of Translational Neurodegeneration, German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany, Department of Neurology, Technische Universität München, Munich, Germany
⨯

Mitochondrial Complex 1 Inhibition Increases 4-Repeat Isoform Tau by SRSF2 Upregulation

Julius Bruch,
Hong Xu,
Anderson De Andrade,
Günter Höglinger

Published: November 17, 2014
https://doi.org/10.1371/journal.pone.0113070

About the Authors

Julius Bruch

Contributed equally to this work with: Julius Bruch, Hong Xu

Affiliations Department of Translational Neurodegeneration, German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany, Department of Neurology, Technische Universität München, Munich, Germany

Hong Xu

Contributed equally to this work with: Julius Bruch, Hong Xu

Anderson De Andrade

Affiliation Department of Translational Neurodegeneration, German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany

Günter Höglinger

* E-mail: hoeglinger@lrz.tum.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JB HX GUH. Performed the experiments: JB HX. Analyzed the data: JB HX ADA. Contributed reagents/materials/analysis tools: ADA. Wrote the paper: JB HX GUH.

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Alternative splicing
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Mitochondria
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Cell differentiation
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Exon mapping
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MTT assay
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Neuronal death
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Neuronal differentiation
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Small interfering RNA
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