About the Authors

Yu-Nong Pang

Affiliation MOE Key Laboratory of Protein Sciences, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Yin-Wen Liang

Affiliation MOE Key Laboratory of Protein Sciences, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Tian-Shi Feng

Affiliation MOE Key Laboratory of Protein Sciences, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Shuang Zhao

Affiliation MOE Key Laboratory of Protein Sciences, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Hao Wu

Affiliation NGM Biopharmaceuticals, Inc., South San Francisco, California, United States of America

Yu-Shuang Chai

Affiliation MOE Key Laboratory of Protein Sciences, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Fan Lei

Affiliation MOE Key Laboratory of Protein Sciences, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Yi Ding

Affiliation Drug Discovery Facility, School of Life Sciences, Tsinghua University, Beijing, China

Dong-Ming Xing

Affiliation MOE Key Laboratory of Protein Sciences, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Li-Jun Du

lijundu@mail.tsinghua.edu.cn

Affiliation MOE Key Laboratory of Protein Sciences, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing, China

Competing Interests

The authors have the following interests. Hao Wu is employed by NGM Biopharmaceuticals, Inc. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: YP LD. Performed the experiments: YP YL YD YC. Analyzed the data: YP TF SZ. Contributed reagents/materials/analysis tools: TF YD FL DX LD. Contributed to the writing of the manuscript: YP YL HW LD.