About the Authors

Toru Ezure

ezure@shimadzu.co.jp (TE); uozumi@biophy.che.tohoku.ac.jp (NU)

Affiliation Clinical and Biotechnology B.U., Shimadzu Corporation, Kyoto, Japan

Kei Nanatani

Affiliation Department of Molecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan

Yoko Sato

Affiliation Department of Molecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan

Satomi Suzuki

Affiliation Department of Microbial Biotechnology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan

Keishi Aizawa

Affiliation Department of Molecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan

Satoshi Souma

Affiliation Department of Molecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan

Masaaki Ito

Current address: Okinawa National College of Technology, Nago-shi, Japan

Affiliation Clinical and Biotechnology B.U., Shimadzu Corporation, Kyoto, Japan

Takahiro Hohsaka

Affiliation School of Materials Science, Japan Advanced Institute of Science and Technology, Ishikawa, Japan

Gunnar von Heijine

Affiliation Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden

Toshihiko Utsumi

Affiliation Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan

Keietsu Abe

Affiliation Department of Microbial Biotechnology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan

Eiji Ando

Affiliation Clinical and Biotechnology B.U., Shimadzu Corporation, Kyoto, Japan

Nobuyuki Uozumi

ezure@shimadzu.co.jp (TE); uozumi@biophy.che.tohoku.ac.jp (NU)

Affiliation Department of Molecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, Japan

Competing Interests

The authors declare that T. Ezure and E. Ando are employees of Shimadzu Corporation, which was one of the funders of this study. This does not alter their adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TE KN YS EA NU. Performed the experiments: TE KN S. Suzuki YS K. Aizawa S. Souma MI. Analyzed the data: TE KN S. Suzuki YS NU. Contributed reagents/materials/analysis tools: TE KN YS MI GH MI TH GH TU K. Abe EA NU. Wrote the paper: TE KN NU.