About the Authors

Zehra Agha

Contributed equally to this work with: Zehra Agha, Zafar Iqbal

These authors are co-first authors on this work

Affiliations Department of Biosciences, Faculty of Science, COMSATS Institute of Information Technology, Islamabad, Pakistan, Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands, Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad, Pakistan

Zafar Iqbal

Contributed equally to this work with: Zehra Agha, Zafar Iqbal

These authors are co-first authors on this work

Affiliation Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands

Maleeha Azam

Affiliation Department of Biosciences, Faculty of Science, COMSATS Institute of Information Technology, Islamabad, Pakistan

Humaira Ayub

Affiliation Department of Biosciences, Faculty of Science, COMSATS Institute of Information Technology, Islamabad, Pakistan

Lisenka E. L. M. Vissers

Affiliation Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands

Christian Gilissen

Affiliation Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands

Syeda Hafiza Benish Ali

Affiliation Department of Biosciences, Faculty of Science, COMSATS Institute of Information Technology, Islamabad, Pakistan

Moeen Riaz

Affiliation Department of Biosciences, Faculty of Science, COMSATS Institute of Information Technology, Islamabad, Pakistan

Joris A. Veltman

Affiliation Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands

Rolph Pfundt

Affiliation Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands

Hans van Bokhoven

h.vanbokhoven@radboudumc.nl (HvB); raheelqamar@hotmail.com (RQ)

Affiliations Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands, Department of Cognitive Neurosciences, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands

Raheel Qamar

h.vanbokhoven@radboudumc.nl (HvB); raheelqamar@hotmail.com (RQ)

Affiliations Department of Biosciences, Faculty of Science, COMSATS Institute of Information Technology, Islamabad, Pakistan, Department of Biochemistry, Al-Nafees Medical College & Hospital, Isra University, Islamabad, Pakistan

Competing Interests

The authors have declared no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZA ZI MA HvB RQ. Performed the experiments: ZA ZI MA HA LELMV CG SHBA MR JAV RP. Analyzed the data: ZA ZI MA HvB RQ. Contributed reagents/materials/analysis tools: HvB RQ. Wrote the paper: ZA ZI MA HvB RQ. Read and approved the final version of the manuscript: ZA ZI MA HA LELMV CG SHBA MR JAV RP HvB RQ.