About the Authors

Kenji Sato

Affiliations Department of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan, Pharmacology Department, Drug Research Center, Kaken Pharmaceutical Co., Ltd., Kyoto, Japan

Mikiro Takaishi

Affiliation Department of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan

Shota Tokuoka

Affiliation Pharmacology Department, Drug Research Center, Kaken Pharmaceutical Co., Ltd., Kyoto, Japan

Shigetoshi Sano

sano.derma@kochi-u.ac.jp

Affiliation Department of Dermatology, Kochi Medical School, Kochi University, Nankoku, Japan

Competing Interests

The authors have read the journal's policy and have the following competing interests: KS and ST are employees of Kaken Pharmaceuticals Co. Ltd. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KS ST SS. Performed the experiments: KS MT. Analyzed the data: KS MT SS. Contributed reagents/materials/analysis tools: ST SS. Contributed to the writing of the manuscript: KS SS.