About the Authors

Anna Casabianca

Contributed equally to this work with: Anna Casabianca, Chiara Orlandi

anna.casabianca@uniurb.it

Affiliation Department of Biomolecular Sciences, University of Urbino “Carlo Bo”, Urbino (PU), Italy

Chiara Orlandi

Contributed equally to this work with: Anna Casabianca, Chiara Orlandi

Affiliation Department of Biomolecular Sciences, University of Urbino “Carlo Bo”, Urbino (PU), Italy

Benedetta Canovari

Affiliation Azienda Ospedaliera Ospedali Riuniti Marche Nord - Presidio Ospedaliero San Salvatore, Pesaro (PU), Italy

Maddalena Scotti

Affiliation Department of Biomolecular Sciences, University of Urbino “Carlo Bo”, Urbino (PU), Italy

Marcello Acetoso

Affiliation Azienda Ospedaliera Ospedali Riuniti Marche Nord - Presidio Ospedaliero San Salvatore, Pesaro (PU), Italy

Massimo Valentini

Affiliation Azienda Ospedaliera Ospedali Riuniti Marche Nord - Presidio Ospedaliero San Salvatore, Pesaro (PU), Italy

Enzo Petrelli

Affiliation Azienda Ospedaliera Ospedali Riuniti Marche Nord - Presidio Ospedaliero San Salvatore, Pesaro (PU), Italy

Mauro Magnani

Affiliation Department of Biomolecular Sciences, University of Urbino “Carlo Bo”, Urbino (PU), Italy

Competing Interests

The work was supported by “Fellowship Program 2011” of Gilead Science Srl. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors have declared that no competing interests exist. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AC CO. Performed the experiments: CO AC MS. Analyzed the data: AC CO. Wrote the paper: AC CO. Collected samples: BC EP MA MV. Managed the patients: BC EP MA MV. Reviewed the manuscript: BC EP MA MV. Performed statistical analysis: CO. Prepared figures: CO. Coordinated and supervised the whole study: MM.