About the Authors

Sarah K. Knutson

Contributed equally to this work with: Sarah K. Knutson, Natalie M. Warholic, L. Danielle Johnston

Affiliation Research and Development, Epizyme Inc., Cambridge, Massachusetts, United States of America

Natalie M. Warholic

Contributed equally to this work with: Sarah K. Knutson, Natalie M. Warholic, L. Danielle Johnston

Affiliation Research and Development, Epizyme Inc., Cambridge, Massachusetts, United States of America

L. Danielle Johnston

Contributed equally to this work with: Sarah K. Knutson, Natalie M. Warholic, L. Danielle Johnston

Affiliation Research and Development, Epizyme Inc., Cambridge, Massachusetts, United States of America

Christine R. Klaus

Affiliation Research and Development, Epizyme Inc., Cambridge, Massachusetts, United States of America

Tim J. Wigle

Affiliation Research and Development, Epizyme Inc., Cambridge, Massachusetts, United States of America

Dorothy Iwanowicz

Affiliation Research and Development, Epizyme Inc., Cambridge, Massachusetts, United States of America

Bruce A. Littlefield

Affiliation Oncology, Eisai Inc., Andover, Massachusetts, United States of America

Margaret Porter-Scott

Affiliation Research and Development, Epizyme Inc., Cambridge, Massachusetts, United States of America

Jesse J. Smith

Affiliation Research and Development, Epizyme Inc., Cambridge, Massachusetts, United States of America

Mikel P. Moyer

Current address: Loxo Oncology, Inc., Boston, Massachusetts, United States of America

Affiliation Research and Development, Epizyme Inc., Cambridge, Massachusetts, United States of America

Robert A. Copeland

Affiliation Research and Development, Epizyme Inc., Cambridge, Massachusetts, United States of America

Roy M. Pollock

Affiliation Research and Development, Epizyme Inc., Cambridge, Massachusetts, United States of America

Kevin W. Kuntz

Affiliation Research and Development, Epizyme Inc., Cambridge, Massachusetts, United States of America

Alejandra Raimondi

Affiliation Research and Development, Epizyme Inc., Cambridge, Massachusetts, United States of America

Heike Keilhack

hkeilhack@epizyme.com

Affiliation Research and Development, Epizyme Inc., Cambridge, Massachusetts, United States of America

Competing Interests

SKK, NMW, LDJ, TJW, CRK, AR, JJS, DI, MPS, RAC, RMP, KWK and HK are employees of Epizyme, Inc. BAL is an employees of Eisai Inc. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SKK AR HK BAL. Performed the experiments: SKK NMW LDJ CRK DI AR. Analyzed the data: SKK NMW LDJ CRK DI AR HK. Contributed reagents/materials/analysis tools: TJW MPM KWK MPS. Wrote the paper: SKK AR LDJ RMP RAC HK JJS.