About the Authors

Shun-Long Weng

Affiliations Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan, Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, Department of Obstetrics and Gynecology, Hsinchu Mackay Memorial Hospital, Hsinchu, Taiwan, Mackay Junior College of Medicine, Nursing and Management, Taipei, Taiwan, Department of Medicine, Mackay Medical College, New Taipei City, Taiwan

Chih-Min Chiu

Affiliation Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan

Feng-Mao Lin

Affiliation Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan

Wei-Chih Huang

Affiliation Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan

Chao Liang

Affiliation Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan

Ting Yang

Affiliation Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan

Tzu-Ling Yang

Affiliation Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan

Chia-Yu Liu

Affiliation Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan

Wei-Yun Wu

Affiliation Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan

Yi-An Chang

Affiliations Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan, Health GeneTech Corporation, Taoyuan, Taiwan

Tzu-Hao Chang

kevinchang@tmu.edu.tw (THC); bryan@mail.nctu.edu.tw (HDH)

Affiliation Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei, Taiwan

Hsien-Da Huang

kevinchang@tmu.edu.tw (THC); bryan@mail.nctu.edu.tw (HDH)

Affiliations Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan, Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan, Center for Bioinformatics Research, National Chiao Tung University, HsinChu, Taiwan

Competing Interests

The authors and the affiliations to Health GeneTech Corporation, along with any other relevant declarations relating to employment, consultancy, patents, products in development or marketed product etc. have declared that no competing interests exist. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SLW THC HDH. Performed the experiments: TY TLY YAC. Analyzed the data: CMC FML WCH CL CYL WYW THC. Contributed reagents/materials/analysis tools: SLW. Wrote the paper: SLW CMC WCH TLY THC HDH.