About the Authors

Annika Kasten

Affiliation Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, Rostock University Medical Center, Rostock, Germany

Cordula Grüttner

Affiliation Micromod Partikeltechnologie GmbH, Rostock, Germany

Jens-Peter Kühn

Affiliation Department of Radiology and Neuroradiology, Greifswald University Medical Center, Greifswald, Germany

Rainer Bader

Affiliation Department of Orthopaedics, Biomechanics and Implant Technology Research Laboratory, Rostock University Medical Center, Rostock, Germany

Juliane Pasold

Affiliation Department of Orthopaedics, Biomechanics and Implant Technology Research Laboratory, Rostock University Medical Center, Rostock, Germany

Bernhard Frerich

bernhard.frerich@med.uni-rostock.de

Affiliation Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, Rostock University Medical Center, Rostock, Germany

Competing Interests

The State Ministry of Economic Affairs, Employment, and Tourism of Mecklenburg-Vorpommern financially supported this work (V-630-S-083-2010/245) within the scope of a specific program which includes besides research institutions also local small and mid-sized companies. Both nanoparticle types were manufactured and provided by Micromod Partikeltechnologie GmbH. Dr. Grüttner characterized the nanoparticles in terms of hydrodynamic particle diameter, polydispersity index, and zeta potential which includes data collection and analysis as well as preparation of the manuscript. The authors state that there are no restrictions on sharing of data and/or materials. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AK CG JPK JP BF. Performed the experiments: AK CG JPK JP. Analyzed the data: AK CG JPK JP BF. Contributed reagents/materials/analysis tools: CG JPK. Wrote the paper: AK CG JPK RB JP BF.