About the Authors

Han-Ching Lin

Affiliation Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan

Tzu-Hung Lin

Affiliation Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan

Ming-Yueh Wu

Affiliation Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan

Yung-Cheng Chiu

Affiliation Department of Orthopaedics, Taichung Veterans General Hospital, Taichung, Taiwan

Chih-Hsin Tang

Affiliation Department of Pharmacology, College of Medicine, China Medical University, Taichung, Taiwan

Mann-Jen Hour

Affiliation School of Pharmacy, College of Medicine, China Medical University, Taichung, Taiwan

Houng-Chi Liou

Affiliation Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan

Huang-Ju Tu

Affiliation Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan

Rong-Sen Yang

rsyang@ntuh.gov.tw (R-SY); wenmei@ntu.edu.tw (W-MF)

Affiliation Department of Orthopedics, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan

Wen-Mei Fu

rsyang@ntuh.gov.tw (R-SY); wenmei@ntu.edu.tw (W-MF)

Affiliation Department of Pharmacology, College of Medicine, National Taiwan University and Hospital, Taipei, Taiwan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Performed the experiments: H.C. Lin THL. Analyzed the data: H.C. Lin THL. Conceived the strategies and designed the experiments of this manuscript: RSY WMF. Prepared the manuscript: H.C. Lin THL. Supervised the project and edited the manuscript: RSY WMF. Performed the animal studies: MYW H.C. Liou HJT. Contributed to obtain the primary cell cultures: YCC CHT. Provided suggestions: MJH.