About the Authors

Kenichi Nakahara

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan

Yasuhiro Fujiwara

yasu@med.osaka-cu.ac.jp

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan

Takuya Tsukahara

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan

Hirokazu Yamagami

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan

Tetsuya Tanigawa

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan

Masatsugu Shiba

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan

Kazunari Tominaga

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan

Toshio Watanabe

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan

Yoshihiro Urade

Affiliations Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Japan, Molecular Sleep Biology Laboratory, International Institute for Integrative Sleep Medicine, World Premier International Research Center, Tsukuba University, Tsukuba, Japan

Tetsuo Arakawa

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan

Competing Interests

Dr. Arakawa received lecture fees from Otsuka and Eisai and research grants from Otsuka, Eisai, Astellas, Abbott Japan, Takeda, Dainippon Sumitomo, and Daiichi Sankyo. The remaining authors have no conflicts to disclose. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KN YF YU. Performed the experiments: KN T. Tsukahara. Analyzed the data: KN. Contributed reagents/materials/analysis tools: KN YF T. Tsukahara HY T. Tanigawa MS KT TW YU TA. Contributed to the writing of the manuscript: KN YF T. Tsukahara HY T. Tanigawa MS KT TW YU TA.