About the Authors

Eleonora Distrutti

eleonoradistrutti@katamail.com

Affiliation S.C. di Gastroenterologia ed Epatologia, Azienda Ospedaliera di Perugia, Perugia, Italy

Julie-Ann O’Reilly

Affiliation Trinity College Institute for Neuroscience, Department of Physiology, Trinity College, Dublin, Ireland

Claire McDonald

Affiliation Trinity College Institute for Neuroscience, Department of Physiology, Trinity College, Dublin, Ireland

Sabrina Cipriani

Affiliation Dipartimento di Medicina, Università degli Studi di Perugia, Perugia, Italy

Barbara Renga

Affiliation Dipartimento di Scienze Chirurgiche e Biomediche, Università degli Studi di Perugia, Perugia, Italy

Marina A. Lynch

Affiliation Trinity College Institute for Neuroscience, Department of Physiology, Trinity College, Dublin, Ireland

Stefano Fiorucci

Affiliation Dipartimento di Scienze Chirurgiche e Biomediche, Università degli Studi di Perugia, Perugia, Italy

Competing Interests

The authors declare that they received funding from a commercial source (CD Investments s.r.l, Rome, Italy). This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ED MAL SF. Performed the experiments: J-AO CM SC BR. Analyzed the data: J-AO CM SC BR ED. Contributed reagents/materials/analysis tools: SF MAL. Contributed to the writing of the manuscript: ED SF MAL. LTP and markers of inflammation in the hippocampus: J-AO CM. PCR on brain genes: SC. Intestinal microbiota composition: BR. Analysis of LTP and markers of inflammation in the hippocampus: J-AO CM. Analysis of global microarray of brain tissue: ED SC. Analysis of PCR on brain genes: SC. Analysis of intestinal microbiota composition: BR.