About the Authors

Srinivas Kammanadiminti

Affiliation Department of Clinical Research, Cangene Corporation, Winnipeg, Manitoba, Canada

Ravi Kumar Patnaikuni

Affiliation Department of Clinical Research, Cangene Corporation, Winnipeg, Manitoba, Canada

Jason Comer

Affiliation Battelle Biomedical Research Center, West Jefferson, Columbus, Ohio, United States of America

Gabriel Meister

Affiliation Battelle Biomedical Research Center, West Jefferson, Columbus, Ohio, United States of America

Chris Sinclair

Affiliation Department of Clinical Research, Cangene Corporation, Winnipeg, Manitoba, Canada

Shantha Kodihalli

skodihalli@ebsi.com

Affiliation Department of Clinical Research, Cangene Corporation, Winnipeg, Manitoba, Canada

Competing Interests

S. Kammanadiminti and R. Patnaikuni were employees of Cangene Corporation at the time of the study, C. Sinclair and S. Kodihalli are employees of Cangene Corporation which manufactured and supplied the AIGIV and placebo employed in these studies. J. Comer was an employee of Battelle Memorial Institute at the time of the study. G. Meister and J. Comer claim no conflict of interest. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: S. Kodihalli CS S. Kammanadiminti. Performed the experiments: JC GM RP. Analyzed the data: GM JC. Contributed reagents/materials/analysis tools: GM JC. Wrote the paper: S. Kodihalli S. Kammanadiminti.