About the Authors

Douglas S. Goodin

Contributed equally to this work with: Douglas S. Goodin, Michael Corwin

douglas.goodin@ucsf.edu

Affiliation Department of Neurology, University of California San Francisco, San Francisco, California, United States of America

Michael Corwin

Contributed equally to this work with: Douglas S. Goodin, Michael Corwin

Affiliations Slone Epidemiology Center at Boston University, Boston, Massachusetts, United States of America, Care-Safe, Boston, Massachusetts, United States of America

David Kaufman

Affiliation Slone Epidemiology Center at Boston University, Boston, Massachusetts, United States of America

Howard Golub

Affiliation Care-Safe, Boston, Massachusetts, United States of America

Shoshana Reshef

Affiliation Bayer HealthCare Pharmaceuticals, Whippany, New Jersey, United States of America

Mark J. Rametta

Affiliation Bayer HealthCare Pharmaceuticals, Whippany, New Jersey, United States of America

Volker Knappertz

Affiliation Teva Pharmaceuticals, Frazer, Pennsylvania, United States of America, Department of Neurology, Heinrich Heine University, Dusseldorf, Germany

Gary Cutter

Affiliation University of Alabama School of Public Health, Birmingham, Alabama, United States of America

Dirk Pleimes

Affiliation Myelo Therapeutics GmbH, Berlin, Germany

Competing Interests

This project was sponsored by Bayer HealthCare Pharmaceuticals, the employer of S Reshef, and MJ Rametta. V Knappertz and D Pleimes were salaried employees of Bayer HealthCare Pharmaceuticals. M Corwin and H Golub are employed by Care-Safe, V Knappertz by Teva Pharmaceutical Industries and D Pleimes by Myelo Therapeutics GmbH. D Goodin has participated (or is currently participating) in several industry-sponsored clinical trials in multiple sclerosis; the sponsoring pharmaceutical companies for these trials have included (or do include) Ares-Serono, Merck Serono, Novartis, Berlex Laboratories, Bayer Schering HealthCare, Biogen Idec, Schering AG, and Teva Neuroscience. He has also lectured at both medical conferences and in public on various aspects of the epidemiology, diagnosis, and management of multiple sclerosis, and in many cases these talks have been sponsored directly or indirectly by one or another of the above listed companies. He has served as a temporary ad hoc consultant to several of these organizations on several occasions. M Corwin has received personal compensation for activities with Bayer HealthCare Pharmaceuticals, Ameritox, and Genova Diagnostics as a consultant. Dr. Corwin has received personal compensation for participation as a Medical Monitor and on Data and Safety Monitoring Committees for Edimer Pharmaceuticals, SynapDx, BioDelivery Sciences International, Stratatech, KV Pharmaceutical, and Meridian Medical Technologies. D Kaufman has received personal compensation for activities with Bayer HealthCare Pharmaceuticals, McNeil Consumer Healthcare, and UCB as a consultant. Dr. Kaufman has received research support from McNeil Consumer HealthCare, CSL Behring, Onyx Pharmaceuticals, Incyte Corporation, and Sanofi-Aventis. H Golub has received personal compensation for activities with Bayer HealthCare Pharmaceuticals, Ameritox, MedicaMetrix, MoMelan Technologies, and Genova Diagnostics as a consultant. Monitoring Committees for Antisense Therapeutics Limited, Sanofi-Aventis, Bayhill Pharmaceuticals, Bayer Pharmaceuticals, BioMS Pharmaceuticals, Daiichi-Sankyo, GlaxoSmithKline Pharmaceuticals, Genmab Biopharmaceuticals, Medivation, Peptimmune, PTC Therapeutics, Teva, Vivus, NHLBI, NINDS, and NMSS. He also received consulting and speaking fees and served on advisory boards for Alexion, Accentia, BaroFold, Ciba Vision, Biogen Idec, Novartis, Consortium of MS Centers (grant), Klein Buendel Incorporated, Enzo Pharmaceuticals, Somnus Pharmaceuticals, and Teva Pharmaceuticals. G Cutter has received personal compensation for participation on Data and Safety. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Performed the experiments: MC DK HG. Analyzed the data: DSG MC DK HG SR MJR VK GC DP. Wrote the paper: DSG MC DK HG SR MJR VK GC DP.