About the Authors

Chengzhi Du

Contributed equally to this work with: Chengzhi Du, Zhen Li

Affiliation Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China

Zhen Li

Contributed equally to this work with: Chengzhi Du, Zhen Li

Affiliation First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China

Shuang Wang

Affiliation Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China

Zhongmei Zhou

Affiliation Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China

Jingkun Wang

Affiliation Yunnan Institute of Materia Medica, Kunming, Yunnan, China

Jian Dong

Affiliation First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China

Ceshi Chen

chenc@mail.kiz.ac.cn

Affiliation Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China

Competing Interests

The authors have the following interests. This study was partially funded by Yunnan Institute of Materia Medica, the manufacturer of the Tongshu Capsule, and employer of Jingkun Wang. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: CC JD. Performed the experiments: CD ZL. Analyzed the data: CD ZL. Contributed reagents/materials/analysis tools: JW SW ZZ. Wrote the paper: CD ZL CC JD.