About the Authors
- Ewa Soltysinska
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Affiliations The Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- Bo Hjorth Bentzen
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Affiliation The Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark
- Maria Barthmes
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Affiliations Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität, Munich, Germany; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany, Nanion Technologies GmbH, Munich, Germany
- Helle Hattel
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Affiliation Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- A. Brianne Thrush
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Affiliation Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada
- Mary-Ellen Harper
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Affiliation Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada
- Klaus Qvortrup
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Affiliation Department of Biomedical Sciences, Core Facility for Integrated Microscopy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- Filip J. Larsen
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Affiliation Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
- Tomas A. Schiffer
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Affiliation Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
- Jose Losa-Reyna
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Affiliation Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
- Julia Straubinger
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Affiliation Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen, Germany
- Angelina Kniess
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Affiliation Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen, Germany
- Morten Bækgaard Thomsen
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Affiliations The Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- Andrea Brüggemann
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Affiliation Nanion Technologies GmbH, Munich, Germany
- Stefanie Fenske
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Affiliation Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität, Munich, Germany; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany
- Martin Biel
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Affiliation Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität, Munich, Germany; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany
- Peter Ruth
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Affiliation Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen, Germany
- Christian Wahl-Schott
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Affiliation Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität, Munich, Germany; Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität, Munich, Germany
- Robert Christopher Boushel
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Contributed equally to this work with: Robert Christopher Boushel, Søren-Peter Olesen, Robert Lukowski
Affiliation Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- Søren-Peter Olesen
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Contributed equally to this work with: Robert Christopher Boushel, Søren-Peter Olesen, Robert Lukowski
* E-mail: spfo@sund.ku.dk (SPO); robert.lukowski@uni-tuebingen.de (RL)
Affiliations The Danish National Research Foundation Centre for Cardiac Arrhythmia, University of Copenhagen, Copenhagen, Denmark, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- Robert Lukowski
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Contributed equally to this work with: Robert Christopher Boushel, Søren-Peter Olesen, Robert Lukowski
* E-mail: spfo@sund.ku.dk (SPO); robert.lukowski@uni-tuebingen.de (RL)
Affiliation Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen, Germany
Competing Interests
BHB and SPO have until 2012 worked at and consulted for NeuroSearch that invented NS11021. MB and AB are employed by Nanion Technologies GmbH: This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: ES BHB M. Barthmes MBT M. Biel PR CWS RCB SPO RL. Performed the experiments: ES BHB M. Barthmes HH ABT MEH KQ FJL TAS JLR JS AK SF RCB RL. Analyzed the data: ES BHB M. Barthmes MBT M. Biel PR CWS RCB SPO RL. Contributed reagents/materials/analysis tools: AB. Wrote the paper: ES BHB M. Barthmes MBT M. Biel PR CWS RCB RL.