About the Authors

Paul R. Kalra

paulkalra@doctors.org.uk

Affiliations Portsmouth Hospitals NHS Trust, Portsmouth, United Kingdom, NHLI Imperial College, ICMS, London, United Kingdom

Xavier García-Moll

Affiliation Unitat Hospitalització, Servei de Cardiologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

José Zamorano

Affiliation University Hospital Ramón y Cajal, Madrid, Spain

Philip A. Kalra

Affiliation Salford Royal NHS Foundation Trust, Salford, United Kingdom

Kim M. Fox

Affiliations NHLI Imperial College, ICMS, London, United Kingdom, Royal Brompton Hospital, London, United Kingdom

Ian Ford

Affiliation University of Glasgow, Glasgow, United Kingdom

Roberto Ferrari

Affiliation Department of Cardiology, Azienda Ospedaliero-Universitaria di Ferrara, Ospedale di Cona, Cona, Italy

Jean-Claude Tardif

Affiliation Montreal Heart Institute, Université de Montreal, Montreal, Canada

Michal Tendera

Affiliation Medical University of Silesia, Katowice, Poland

Nicola Greenlaw

Affiliation University of Glasgow, Glasgow, United Kingdom

Ph. Gabriel Steg for the CLARIFY Investigators

Membership of the CLARIFY Investigators is included in Table S1.

Affiliations Royal Brompton Hospital, London, United Kingdom, Université Paris-Diderot, Sorbonne-Paris Cité, Paris, France, INSERM U-1148, Paris, France, Département Hospitalo-Universitaire FIRE, Hôpital Bichat, Assistance Publique – Hôpitaux de Paris, Paris, France

Competing Interests

PRK reports research grants from Servier; consultancy fees/honoraria from A Menarini and Servier. Support for travel to meetings from Servier. XG-M reports advisory and conference fees from Servier. JZ reports speaker fees from Servier. IF reports research grants, honoraria for committee membership, and support for conference attendance from Servier. RF reports Speaker's bureau for Servier, Novartis, Merck Serono; research grants from Servier, Boehringer Ingelheim; and advisory board for Servier, Boehringer Ingelheim and Novartis. J-CT reports that his institution received grants and consulting fees from Servier; he also received a consulting fee or honorarium from Servier; support for travel to meetings for the study or other purposes from Servier; and payment for lectures from Servier. MT reports fees, honoraria, and research grants from Amgen, Bayer, and Servier. PGS reports that his institution received grants and consulting fees from Servier; he also received a consulting fee or honorarium from Servier; support for travel to meetings for the study or other purposes from Servier; and payment for lectures from Servier. The authors declare that the affiliations to the funding organization (Servier) and the declarations provided in the competing interests form do not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PRK XG-M JZ PAK KMF IF RF J-CT MT PGS. Performed the experiments: PRK XG-M JZ PAK KMF IF RF J-CT MT NG PGS. Analyzed the data: NG IF. Wrote the paper: PRK XG-M PAK KMF IF MT NG PGS.