About the Authors

Rosa Solà

rosa.sola@urv.cat

Affiliation Unitat de Recerca de Lipids i Arteriosclerosi, CIBERDEM, Servei de Medicina Interna, Hospital Universitari de San Joan, IISPV, Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain

Rosa-M Valls

Affiliation Unitat de Recerca de Lipids i Arteriosclerosi, CIBERDEM, Servei de Medicina Interna, Hospital Universitari de San Joan, IISPV, Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain

José Puzo

Affiliation Unidad de Lípidos y Laboratorio de Bioquímica, Hospital Universitario San Jorge, Huesca, Spain

José-Ramón Calabuig

Affiliation Departamento de Medicina Interna, Hospital Universitario y Politécnico La Fe, Valencia, Spain

Angel Brea

Affiliation Unidad de Lípidos, Servicio de Medicina Interna, Hospital Universitario San Pedro, Logroño, Spain

Anna Pedret

Affiliation Unitat de Recerca de Lipids i Arteriosclerosi, CIBERDEM, Servei de Medicina Interna, Hospital Universitari de San Joan, IISPV, Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain

David Moriña

Affiliation Centre Tecnològic de Nutrició i Salut, Reus, Spain

José Villar

Affiliation Unidad de Hipertensión y Lípidos, Hospital Universitario Virgen del Rocio, Sevilla, Spain

Jesús Millán

Affiliation Servicio de Medicina Interna, Hospital Universitario Gregorio Marañón, Madrid, Spain

Anna Anguera

Affiliation Medical Department, Rottapharm S.L., Barcelona, Spain

Competing Interests

Dr. Anna Anguera is the only employee of Rottapharm S.L. She individually participated in the study as an expert on the use of the product in the trial. Rottapharm S.L. as a corporate entity had no role in the manuscript preparation and the decision to submit it for publication. The authors also declare there have not been any other involvements such as employment, consultancy and patent products that can be construed as a conflict of interest. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. Moreover, the authors declare that there are no restrictions on sharing of data and/or materials.

Author Contributions

Conceived and designed the experiments: RS and R-MV were responsible for study design including project conception, development of overall research plan, and study oversight;. Performed the experiments: RS, R-MV, JP, J-RC, AB, DM, AP, JM, JV and AA were responsible for the revision of study design, the execution of the study including hands-on conduct of the experiments. Analyzed the data: DM analyzed data and performed the statistical analyses;. Contributed reagents/materials/analysis tools: RS, R-MV, JP, J-RC, AB, DM, AP, JM, JV and AA were responsible for the data collection and interpretation of data;. Wrote the paper: RS, AA, AP and R-MV drafted the manuscript and DM, JP, J-RC, AB, JM and JV revised the manuscript critically providing important intellectual content. RS and R-MV were responsible for study design including project conception, development of overall research plan, and study oversight; RS, R-MV, JP, J-RC, AB, DM, AP, JM, JV and AA were responsible for the revision of study design, the execution of the study including hands-on conduct of the experiments, data collection and interpretation of data; DM analyzed data and performed the statistical analyses; RS, AA, AP and R-MV drafted the manuscript and DM, JP, J-RC, AB, JM and JV revised the manuscript critically providing important intellectual content; RS had primary responsibility for final content. All authors have read and approved the final manuscript.