About the Authors

Anja Derer

Affiliations Department of Internal Medicine 3 and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany, Department of Radiation Oncology, University Hospital Erlangen, Erlangen, Germany

Bettina Groetsch

Affiliation Department of Internal Medicine 3 and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany

Ulrike Harre

Affiliation Department of Internal Medicine 3 and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany

Christina Böhm

Affiliation Department of Internal Medicine 3 and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany

Jennifer Towne

Affiliation Department of Inflammation Research, Amgen Inc., Longmont, Colorado, United States of America

Georg Schett

Affiliation Department of Internal Medicine 3 and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany

Silke Frey

Contributed equally to this work with: Silke Frey, Axel J. Hueber

Affiliation Department of Internal Medicine 3 and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany

Axel J. Hueber

Contributed equally to this work with: Silke Frey, Axel J. Hueber

axel.hueber@uk-erlangen.de

Affiliation Department of Internal Medicine 3 and Institute for Clinical Immunology, University Hospital Erlangen, Erlangen, Germany

Competing Interests

Jennifer Towne is an employee of Amgen, Inc. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AJH JT GS. Performed the experiments: AD BG UH CB. Analyzed the data: AD GS SF AJH. Contributed reagents/materials/analysis tools: JT. Contributed to the writing of the manuscript: AD SF AJH. Critically read, discussed, revised, and approved the final manuscript: AD BG UH CB JT GS SF AJH.