About the Authors

Sajjad Rafiq

Affiliation Genetic Epidemiology and Bioinformatics Research Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Hants, United Kingdom

Sofia Khan

Affiliation Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

William Tapper

Affiliation Genetic Epidemiology and Bioinformatics Research Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Hants, United Kingdom

Andrew Collins

Affiliation Genetic Epidemiology and Bioinformatics Research Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Hants, United Kingdom

Rosanna Upstill-Goddard

Affiliation Genetic Epidemiology and Bioinformatics Research Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Hants, United Kingdom

Susan Gerty

Affiliation Clinical Trials Unit, Faculty of Medicine, University of Southampton, Hants, United Kingdom

Carl Blomqvist

Affiliation Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland

Kristiina Aittomäki

Affiliation Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland

Fergus J. Couch

Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

Jianjun Liu

Affiliation Human Genetics, Genome Institute of Singapore, Singapore

Heli Nevanlinna

Contributed equally to this work with: Heli Nevanlinna, Diana Eccles

Affiliation Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

Diana Eccles

Contributed equally to this work with: Heli Nevanlinna, Diana Eccles

d.m.eccles@soton.ac.uk

Affiliation Cancer Sciences Division, University of Southampton, School of Medicine, Southampton General Hospital, Hants, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DE HN AC SR WT. Performed the experiments: SR SK RUG SG KA FJC JL. Analyzed the data: SR SK WT. Contributed reagents/materials/analysis tools: FJC JL DE HN SG KA CB. Wrote the paper: SR SK HN DE.