About the Authors

Zheng Shen

Affiliation Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America

John V. Fahey

Affiliation Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America

Jack E. Bodwell

Affiliation Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America

Marta Rodriguez-Garcia

Affiliation Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America

Angela D. M. Kashuba

Affiliation Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, Chapel Hill, North Carolina, United States of America

Charles R. Wira

Charles.R.Wira@Dartmouth.edu

Affiliation Department of Physiology and Neurobiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts: A.D.M.K. is a paid consultant to Gilead. Patents related to the drugs TDF and FTC are held by Gilead. This does not alter the authors' adherence to all PLOS policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ZS JVF JEB MRG CRW. Performed the experiments: ZS MRG. Analyzed the data: ZS JVF JEB MRG ADMK CRW. Contributed reagents/materials/analysis tools: ADMK. Wrote the paper: ZS JVF JEB MRG ADMK CRW.