About the Authors

Toshiya Okumura

Affiliations Department of Cellular and Molecular Pharmacology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan, Department of Oral Surgery, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

Kae Harada

Affiliation Department of Cellular and Molecular Pharmacology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

Kana Oue

Affiliations Department of Cellular and Molecular Pharmacology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan, Department of Dental Anesthesiology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

Jun Zhang

Affiliation Department of Cellular and Molecular Pharmacology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

Satoshi Asano

Affiliation Department of Cellular and Molecular Pharmacology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

Masaki Hayashiuchi

Affiliation Department of Cellular and Molecular Pharmacology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

Akiko Mizokami

Affiliation Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan

Hiroto Tanaka

Affiliations Department of Cellular and Molecular Pharmacology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan, Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan

Masahiro Irifune

Affiliation Department of Dental Anesthesiology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

Nobuyuki Kamata

Affiliation Department of Oral Surgery, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

Masato Hirata

Affiliation Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan

Takashi Kanematsu

tkanema2@hiroshima-u.ac.jp

Affiliation Department of Cellular and Molecular Pharmacology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TK TO. Performed the experiments: TO KH KO JZ M. Hayashiuchi AM. Analyzed the data: TO KH KO JZ SA HT. Contributed reagents/materials/analysis tools: MI NK M. Hirata. Wrote the paper: TK M. Hirata.