About the Authors

Bee Luan Khoo

Contributed equally to this work with: Bee Luan Khoo, Majid Ebrahimi Warkiani, Daniel Shao-Weng Tan

Affiliation Mechanobiology Institute, National University of Singapore, Singapore, Singapore

Majid Ebrahimi Warkiani

Contributed equally to this work with: Bee Luan Khoo, Majid Ebrahimi Warkiani, Daniel Shao-Weng Tan

Affiliation BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore, Singapore

Daniel Shao-Weng Tan

Contributed equally to this work with: Bee Luan Khoo, Majid Ebrahimi Warkiani, Daniel Shao-Weng Tan

Affiliations Department of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore, Cancer Therapeutics Research Laboratory, National Cancer Centre Singapore, Singapore, Singapore

Ali Asgar S. Bhagat

Affiliation Clearbridge BioMedics Pte Ltd, Singapore, Singapore

Darryl Irwin

Affiliation Sequenom Inc, San Diego, California, United States of America

Dawn Pingxi Lau

Affiliations Department of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore, Cancer Therapeutics Research Laboratory, National Cancer Centre Singapore, Singapore, Singapore

Alvin S. T. Lim

Affiliation Department of Pathology, Singapore General Hospital, Singapore, Singapore

Kiat Hon Lim

Affiliation Department of Pathology, Singapore General Hospital, Singapore, Singapore

Sai Sakktee Krisna

Affiliations Department of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore, Cancer Therapeutics Research Laboratory, National Cancer Centre Singapore, Singapore, Singapore

Wan-Teck Lim

Affiliation Department of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore

Yoon Sim Yap

Affiliation Department of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore

Soo Chin Lee

Affiliation Department of Hematology-Oncology, National University Hospital, Singapore, Singapore

Ross A. Soo

Affiliation Department of Hematology-Oncology, National University Hospital, Singapore, Singapore

Jongyoon Han

jyhan@mit.edu (JH); ctlim@nus.edu.sg (CTL)

Affiliations BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore, Singapore, Department of Electrical Engineering and Computer Science, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Chwee Teck Lim

jyhan@mit.edu (JH); ctlim@nus.edu.sg (CTL)

Affiliations Mechanobiology Institute, National University of Singapore, Singapore, Singapore, BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore, Singapore, Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore, Clearbridge BioMedics Pte Ltd, Singapore, Singapore

Competing Interests

AASB is an employee of Clearbridge BioMedics Pte Ltd which commercialized the technology described here. AASB, JH and CTL, along with others, also have filed a patent application on the technology. Pending patent: Microfluidics Sorter for Cell Detection and Isolation and number PCT/US2011/027276. A product based on this technology is currently being developed by Clearbridge Biomedics Pte Ltd. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: BLK MEW DSWT JH CTL. Performed the experiments: BLK MEW DI. Analyzed the data: BLK MEW DSWT CTL. Contributed reagents/materials/analysis tools: DSWT AASB DI DPL ASTL KHL SSK WTL YSY SCL RAS CTL. Wrote the paper: BLK MEW DSWT JH CTL.