About the Authors

Longchuan Bai

Affiliation University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Jianfang Chen

Affiliation University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Donna McEachern

Affiliation University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Liu Liu

Affiliation University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Haibin Zhou

Affiliation University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Angelo Aguilar

Affiliation University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

Shaomeng Wang

shaomeng@umich.edu

Affiliations University of Michigan Comprehensive Cancer Center and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America, University of Michigan Comprehensive Cancer Center and Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, United States of America, University of Michigan Comprehensive Cancer Center and Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America

Competing Interests

Ascentage Pharma has licensed the Bcl-2/Bcl-XL inhibitor technology from the University of Michigan. Dr. Wang receives compensation and owns stock in Ascentage. All other authors declare no conflict of interest. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SW LB. Performed the experiments: LB JC DM LL. Analyzed the data: LB SW. Contributed reagents/materials/analysis tools: HZ AA. Wrote the paper: LB SW.