About the Authors

Xing Qiu

xqiu@bst.rochester.edu

Affiliation Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, United States of America

Rui Hu

Affiliation Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York, United States of America

Zhixin Wu

Affiliation Math Department, DePauw University, Greencastle, Indiana, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XQ. Performed the experiments: XQ RH. Analyzed the data: XQ RH. Wrote the paper: XQ RH ZW. Contributed equally to the theoretical derivations of the large-sample properties of normalization procedures: XQ RH ZW.