About the Authors

Osama M. A. Ibrahim

OMAI and MD contributed equally to this work and are joint first authors.

Affiliation Keio University School of Medicine, Department of Ophthalmology, Tokyo, Japan

Murat Dogru

muratodooru2012@yahoo.com

OMAI and MD contributed equally to this work and are joint first authors.

Affiliations Keio University School of Medicine, Department of Ophthalmology, Tokyo, Japan, Tokyo Dental College, Department of Ophthalmology, Chiba, Japan

Yukihiro Matsumoto

Affiliation Keio University School of Medicine, Department of Ophthalmology, Tokyo, Japan

Ayako Igarashi

Affiliation Tokyo Dental College, Department of Ophthalmology, Chiba, Japan

Takashi Kojima

Affiliation Keio University School of Medicine, Department of Ophthalmology, Tokyo, Japan

Tais Hitomi Wakamatsu

Affiliation Keio University School of Medicine, Department of Ophthalmology, Tokyo, Japan

Takaaki Inaba

Affiliation Keio University School of Medicine, Department of Ophthalmology, Tokyo, Japan

Takahiko Shimizu

Affiliation Department of Advanced Aging Medicine, Chiba University Graduate School of Medicine; Chiba, Japan

Jun Shimazaki

Affiliation Tokyo Dental College, Department of Ophthalmology, Chiba, Japan

Kazuo Tsubota

Affiliation Keio University School of Medicine, Department of Ophthalmology, Tokyo, Japan

Competing Interests

Johnson and Johnson (J&J) Vision Care Company made a grant donation to Keio University School of Medicine, Department of Ophthalmology, for the conduct of the animal study and for the purchase of antibodies and solutions. J&J was not involved with the scientific content of the research projects run by the Ophthalmology department of Keio University School of Medicine. The authors were not paid employees and did not receive any kind of fees from J&J. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: OMAI MD YM TK TS JS KT. Analyzed the data: OMAI MD YM AI TK THW TI TS JS KT. Wrote the paper: OMAI. Revised article critically for important intellectual content: MD YM AI TK THW TI TS JS KT. Final approval of the manuscript: OMAI MD YM AI TK THW TI TS JS KT.