About the Authors

Nobuhiro Ooba

n-ooba@umin.net

Affiliation Department of Pharmacoepidemiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

Tsugumichi Sato

Affiliations Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan, Drug Safety Research Unit Japan, Tokyo, Japan

Akira Wakana

Affiliation MSD K.K., Tokyo, Japan

Takao Orii

Affiliation NTT Medical Center Tokyo, Tokyo, Japan

Masaki Kitamura

Affiliation Department of Pharmacy, The Jikei University School of Medicine, Tokyo, Japan

Akira Kokan

Affiliation EliLilly Japan, K.K., Hyogo, Japan

Hideaki Kurata

Affiliation Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan

Yoshihiro Shimodozono

Affiliation Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

Kenichi Matsui

Affiliation Office for Promoting Medical Research, Showa University, Tokyo, Japan

Hiroshi Yoshida

Affiliation Department of Laboratory Medicine, The Jikei University Kashiwa Hospital, Chiba, Japan

Takuhiro Yamaguchi

Affiliation Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japan

Shigeru Kageyama

Affiliation Division of Clinical Pharmacology and Therapeutics, The Jikei University School of Medicine, Tokyo, Japan

Kiyoshi Kubota

Affiliation Department of Pharmacoepidemiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

Competing Interests

This study was conducted by the unconditional research funding provided from Astellas Pharma Japan, AstraZeneca Japan, Daiichi-Sankyo Japan, Kowa Pharmaceutical and Shionogi. HY received a research grant from Astellas Pharma Japan, Kowa Pharmaceutical, Shionogi and MSD. SK received a research grant from Pfizer. AW is an employee of MSD K.K. AK is an employee of Eli Lilly Japan. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NO TS AW TO MK AK HK YS KM HY TY SK KK. Performed the experiments: NO TS MK YS SK KK. Analyzed the data: NO TS AW TY KK. Wrote the paper: NO TS AW TO MK AK HK YS KM HY TY SK KK.