About the Authors

Duane D. Hall

Affiliation Department of Internal Medicine, Division of Cardiovascular Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Yuejin Wu

Affiliation Department of Internal Medicine, Division of Cardiovascular Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Frederick E. Domann

mark-e-anderson@uiowa.edu (MEA); frederick-domann@uiowa.edu (FED); douglas-spitz@uiowa.edu (DRS)

Affiliation Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Douglas R. Spitz

mark-e-anderson@uiowa.edu (MEA); frederick-domann@uiowa.edu (FED); douglas-spitz@uiowa.edu (DRS)

Affiliation Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Mark E. Anderson

mark-e-anderson@uiowa.edu (MEA); frederick-domann@uiowa.edu (FED); douglas-spitz@uiowa.edu (DRS)

Affiliations Department of Internal Medicine, Division of Cardiovascular Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Competing Interests

DDH, FED, DRS, and MEA declare that they are co-inventors of a pending utility patent application entitled 'Modulation of the mitochondrial calcium uniporter for the treatment of diseases and disorders associated with CaMKII activity.' This does not alter the authors' adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DH FD DS MA. Performed the experiments: DH YW. Analyzed the data: DH YW MA. Contributed reagents/materials/analysis tools: DH FD MA. Wrote the paper: DH FD DS MA.