About the Authors

Dina Zielinski

Affiliation Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

Barak Markus

Affiliation Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

Mona Sheikh

Affiliation Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

Melissa Gymrek

Affiliations Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Harvard-MIT Division of Health Sciences and Technology, MIT, Cambridge, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Molecular Biology and Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Clement Chu

Affiliation Counsyl, South San Francisco, California, United States of America

Marta Zaks

Affiliation Rambam Health Care Campus, Haifa, Israel

Balaji Srinivasan

Affiliation Counsyl, South San Francisco, California, United States of America

Jodi D. Hoffman

Affiliation Division of Genetics, Tufts Medical Center, Boston, Massachusetts, United States of America

Dror Aizenbud

Contributed equally to this work with: Dror Aizenbud, Yaniv Erlich

Affiliation Rambam Health Care Campus, Haifa, Israel

Yaniv Erlich

Contributed equally to this work with: Dror Aizenbud, Yaniv Erlich

yaniv@wi.mit.edu

Affiliation Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

Competing Interests

The study was funded by Whitehead Institute internal funds and private donations from Andria and Paul Heafy, Cathy and Jim Stone, and Ron Casty. Two authors, Drs. Balaji Srinivasan and Clement Chu, are from Counsyl Inc, a for-profit company. Their role in the manuscript was generation of the sequencing data. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. They did not participate in the interpretation of the results. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DZ YE. Performed the experiments: DZ MZ DA. Analyzed the data: DZ BM MS MG YE JH. Contributed reagents/materials/analysis tools: CC BS. Wrote the paper: DZ YE.