About the Authors

Aldric T. Hama

ahama@miami.edu

Affiliation Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Peter Germano

Affiliation Ironwood Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Matthew S. Varghese

Affiliation Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Benjamin F. Cravatt

Affiliation Department of Chemical Physiology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

G. Todd Milne

Affiliation Ironwood Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

James P. Pearson

Affiliation Ironwood Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Jacqueline Sagen

Affiliation Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America

Competing Interests

The current work was supported in part by Ironwood Pharmaceuticals, Inc. Co-authors Peter Germano, James P. Pearson and G. Todd Milne are stockholders, Peter Germano and G. Todd Milne are employees, and James P. Pearson is a paid consultant of Ironwood Pharmaceuticals which has a FAAH inhibitor program. The specific roles of these authors are articulated in the ‘author contributions’ section. Ironwood provided research materials required per the study design. There are no patents, products in development or marketed products to declare that would represent a conflict of interest. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ATH PG GTM JPP JS. Performed the experiments: ATH PG MV. Analyzed the data: MV ATH JPP GTM JS. Contributed reagents/materials/analysis tools: BFC. Wrote the paper: JS ATH GTM JPP.