About the Authors

Casey P. Shannon

Affiliations PROOF Centre of Excellence, Vancouver, BC, Canada, UBC James Hogg Centre for Heart Lung Innovations, Vancouver, BC, Canada

Robert Balshaw

Affiliations PROOF Centre of Excellence, Vancouver, BC, Canada, Department of Statistics, University of British Columbia, Vancouver, BC, Canada

Raymond T. Ng

Affiliations PROOF Centre of Excellence, Vancouver, BC, Canada, Department of Computer Science, University of British Columbia, Vancouver, BC, Canada, UBC James Hogg Centre for Heart Lung Innovations, Vancouver, BC, Canada

Janet E. Wilson-McManus

Affiliations PROOF Centre of Excellence, Vancouver, BC, Canada, UBC James Hogg Centre for Heart Lung Innovations, Vancouver, BC, Canada

Paul Keown

Affiliations PROOF Centre of Excellence, Vancouver, BC, Canada, Department of Medicine, Division of Nephrology, University of British Columbia, Vancouver, BC, Canada

Robert McMaster

Affiliations PROOF Centre of Excellence, Vancouver, BC, Canada, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada

Bruce M. McManus

Affiliations PROOF Centre of Excellence, Vancouver, BC, Canada, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, UBC James Hogg Centre for Heart Lung Innovations, Vancouver, BC, Canada

David Landsberg

Affiliation Division of Nephrology, St. Paul's Hospital, and University of British Columbia, Vancouver, BC, Canada

Nicole M. Isbel

Affiliation Department of Nephrology, Princess Alexandra Hospital, and University of Queensland, Brisbane, Australia

Greg Knoll

Affiliation Ottawa Hospital Research Institute, Ottawa, On, Canada

Scott J. Tebbutt

scott.tebbutt@hli.ubc.camailto

Affiliations PROOF Centre of Excellence, Vancouver, BC, Canada, Department of Medicine, Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada, UBC James Hogg Centre for Heart Lung Innovations, Vancouver, BC, Canada

Competing Interests

Funding for this work was provided by Genome Canada, Genome British Columbia, and the NCE CECR Program. The following commercial partners also provided funding: Novartis Pharma AG and IBM. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There is no intellectual property related to the work presented in this manuscript. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CSP RTN SJT. Performed the experiments: CSP. Analyzed the data: CSP RB RTN SJT. Contributed reagents/materials/analysis tools: JWM PK RM BMM DL NMI GK. Wrote the paper: CSP SJT.