About the Authors

Jens Durruthy-Durruthy

Affiliation Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology and Department of Genetics, Stanford University, Stanford, California, United States of America

Sharon F. Briggs

Affiliation Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology and Department of Genetics, Stanford University, Stanford, California, United States of America

Jason Awe

Affiliations Eli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research, University of California Los Angeles, Los Angeles, California, United States of America, Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

Cyril Y. Ramathal

Affiliation Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology and Department of Genetics, Stanford University, Stanford, California, United States of America

Saravanan Karumbayaram

Affiliations Eli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research, University of California Los Angeles, Los Angeles, California, United States of America, Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, United States of America

Patrick C. Lee

Affiliations Eli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research, University of California Los Angeles, Los Angeles, California, United States of America, Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

Julia D. Heidmann

Affiliation Veterans Affairs Palo Alto Health Care System, Stanford University, Palo Alto, California, United States of America

Amander Clark

Affiliations Eli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research, University of California Los Angeles, Los Angeles, California, United States of America, Department of Molecular, Cellular, and Developmental Biology, Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

Ioannis Karakikes

Affiliations Stanford Cardiovascular Institute, Stanford University, Stanford, California, United States of America, Department of Cardiology, Department of Medicine, Stanford University, Stanford, California, United States of America

Kyle M. Loh

Affiliation Department of Developmental Biology, Stanford University, Stanford, California, United States of America

Joseph C. Wu

Affiliations Stanford Cardiovascular Institute, Stanford University, Stanford, California, United States of America, Department of Cardiology, Department of Medicine, Stanford University, Stanford, California, United States of America

Andrew R. Hoffman

Affiliation Veterans Affairs Palo Alto Health Care System, Stanford University, Palo Alto, California, United States of America

James Byrne

Affiliations Eli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research, University of California Los Angeles, Los Angeles, California, United States of America, Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

Renee A. Reijo Pera

Affiliation Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology and Department of Genetics, Stanford University, Stanford, California, United States of America

Vittorio Sebastiano

vsebast@stanford.edu

Affiliation Institute for Stem Cell Biology and Regenerative Medicine, Department of Obstetrics and Gynecology and Department of Genetics, Stanford University, Stanford, California, United States of America

Competing Interests

Renee A. Reijo Pera is on the PLOS ONE Editorial Board. This does not alter the authors′ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JDD JB RARP VS. Performed the experiments: JDD SFB JA CYR SK PCL JDH AC IK KML. Analyzed the data: JDD SFB SK IK KML. Contributed reagents/materials/analysis tools: JDH ARH. Wrote the paper: JDD SK JB RARP VS. Final approval of manuscript: JB RARP VS JCW.